Frontrunners Radcliffe were spared of yet more blushes last weekend, as they bounced back from defeat with a 3-2 victory over Bamber Bridge.
They will look to further their lead at the top of the table as they travel to Guiseley, who themselves could break into a playoff spot with a victory at Nethermoor Park.
Closest challengers Warrington Rylands could close the gap to the Boro as they journey to face Bradford Park Avenue, who are without a win in four games and currently sit in 19th place.
Despite sitting in third place, Worksop Town have only managed to pick up two points from their previous four outings and will be hoping to turn their form around as they travel to face Ashton United.
Towards the bottom of the division, Stafford Rangers will begin life under new manager Dave Cooke, who was appointed on Monday, by welcoming Marske United to Marston Road in a battle between 21st versus 18th.
With both teams picking up wins in their previous fixtures, it could prove to be an intriguing battle in the race for survival in the Northern Premier League.
Another team hoping to avoid the drop is Basford United who just missed out on claiming an important three points last time out against Warrington Rylands.
The Lions will host Whitby Town who are unbeaten in four games.
All fixtures will take place on Saturday 2 December at 3pm, unless stated otherwise. With many teams imposing pitch inspections, fans should keep an eye on their relative club social media accounts for further updates regarding postponements.
Fixtures - Saturday 2 December
Ashton United v Worksop Town
Bamber Bridge v Macclesfield
Basford United v Whitby Town
Bradford Park Avenue v Warrington Rylands
Gainsborough Trinity v FC United of Manchester
Guiseley v Radcliffe
Marine v Ilkeston Town
Matlock Town v Lancaster City
Morpeth Town v Atherton Collieries
Stafford Rangers v Marske United
Workington v Hyde United