Back in 1967 it was Enfield who claimed the cup with a 3-0 win at Maine Road following a 0-0 draw at Wembley in front of 75,000 supporters seven days earlier on Saturday 22 April 1967.
After taking on the Ryman Premier's Towners, the successor club founded by fans of the original Enfield, Skem are set to travel south next summer to their Queen Elizabeth II Stadium.
Skem are hoping for a bumper turn-out next Saturday as they remember one of the biggest days in their history which saw a mass exodus from the Lancashire town to Wembley.
Officials say many of the players who were in action that day have pledged to be at Stormy Corner for the reunion match including Alan Bermingham, John Unsworth, Richie Wade, Dave Moorcroft, Micky Worswick, Wally Bennett, Micky Burns and Alan McDermott.
Skem, coached by Liverpool legend Ian St John on their route to the final, went on to lift the FA Amateur Cup four years later when they beat Dagenham at Wembley in 1971.
Skelmersdale United press officer Neil Leatherbarrow said: "It was one to remember, the day Skelmersdale left en bloc for London. It was a massive thing for the town and almost 50 years later this is arguably the era when Skelmersdale have had our best team since then. We're hoping for a big crowd to celebrate a special day."
Images courtesy of Skelmersdale United FC
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