At the top of the table on goals difference and with two wins, Buxton travel to FC United of Manchester who have began their campaign with one draw and one win, the latter coming mid-week against Morpeth Town.
South Shields travel to Witton Albion, while Warrington Town make the trip to the Flamingo Land Stadium to face Scarborough Athletic.
Nantwich Town, the last of the four looking to make it a perfect start to the new campaign, travel to Whitby Town.
In fifth spot, Ashton United have started their 2021/22 season with a win over Matlock and a draw to Scarborough, and they face Mickelover at the Don Amott Arena.
Stafford Rangers will be looking to bounce back from their mid-week 1-0 defeat at home to the Yellows as they host Radcliffe.
Stalybridge Celtic host Morpeth Town, with both sides searching for their opening points of the season on Saturday, while Atherton Collieries face Basford United.
Elsewhere in the league, Matlock Town face Hyde United, Lancaster City travel to Grantham Town and Bamber Bridge host Gainsborough Trinity.
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