Brodie, 35, helped both Crawley Town and Fleetwood Town to promotion to the Football League during his playing career.
He has played for a host of clubs, including two seasons at Skelmersdale towards the end of his career.
Recently, he has been a first team coach with Ashton Athletic.
Skelmersdale tweeted: “We are delighted to announce the appointment of Richard Brodie as First Team Manager.
“Many of you will be familiar with Richard Brodie as a former player and coach for the blues.
“Richard will start his journey with us tomorrow night at the Runcorn Linnets game.”
Brodie succeeds Paul McNally, who left Skelmersdale to take charge at NPL West Division rivals City of Liverpool over the weekend.
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