League leaders Ilkeston Town travel to second from bottom Soham Town Rangers.
Halesowen Town, sat in second only on goal difference to Ilkeston, have a harder task as they face 13th-place Yaxley.
Only three points behind in third, Chasetown will aim to keep
the heat on the top two.
Histon are the hosts for the Scholars, they sit rock bottom of the league, seven points off safety.
Wisbech Town, who make up the bottom three, will have eighth place Bedworth United travelling to the Fenland Stadium.
Fourth play fifth in a hotly anticipated tie - Belper Town and Stamford are only separated by three points as they fight for a play-off place.
Carlton Town will hope to carry on their impressive away record. The Millers have only lost two away games and their opponents, Loughborough Dynamo, are without a win in two.
Just above the relegation zone in 17th, Daventry Town will host mid-table side Spalding United.
Level on the points with the Purple Army, Sutton Coldfield Town clash with Sporting Khalsa.
Shepshed Dynamo will hope to avoid another draw, after nine already this season, when they play Cambridge City at the Dovecote Stadium.
Meanwhile, Coleshill Town, without a win in four, take the trip to 15th-place Corby Town this weekend.
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