There are just two games in the Premier Division, with Gainsborough Trinity hosting Stalybridge Celtic in a battle of 19th v 16th respectively.
Stalybridge Celtic this weekend appointed Stephen O’Halloran as their new player-assistant manager.
Elsewhere in the Premier Division, second-placed Matlock Town broke club records recently with their 9-0 victory over Witton Albion. The side, who recently added Ioan Evans to their squad after losing Sam Egerton, travel to Stafford Rangers.
In the East Division, there are four fixtures this weekend.
In third place, Shildon A.F.C. travel to Bridlington Town, who are still searching for their first win of the season and sit at the bottom of the table.
Dunston host Frickley Athletic, while fourth take on fifth in the fixture of Ossett United and Yorkshire Amateur respectively at Infield.
Elsewhere, Tadcaster Albion host Lincoln United.
In the Midlands Division, second-placed Coleshill Town have recorded six wins so far this season and will be looking to add to that as they host Yaxley.
Carlton Town host Ilkeston Town, while Shepshed Dynamo face Histon.
With one win so far this season and at the bottom of the table, Wisbech Town travel to Daventry Town.
In the West Division, top of the table Workington remain unbeaten so far in the 2021/22 season and travel to Widnes, who have a record of one win, one draw and five losses so far this season and will have new manager Dave Dempsey in charge.
Kendal Town host Clitheroe, while Leek Town travel to Newcastle Town.
Warrington Rylands this week added defender Sam Egerton to their squad from Matlock Town, making his debut midweek against Kendal Town. Rylands face Trafford this weekend.
Bootle this week appointed Brian Richardson as their new manager, and his first game in charge will come with a visit to Market Drayton Town.
Finally, Glossop North End travel to Ramsbottom United.