Second-placed Whitby face fifth-placed Matlock, with both sides looking to continue their play-off form and cement their place early in the season.
The longest serving members of the BetVictor Northern Premier in Whitby have won six of their opening eight fixtures, and are only behind table toppers South Shields on goal difference.
The Seasiders are on a eight-game winning streak, including their FA Cup win at 1874 Northwich, and face the Gladiators who recently drew to Atherton Collieries and have 15 league points.
Just behind Matlock are Warrington Town, who travel to the Flamingo Land Stadium to face Scarborough Athletic and a win could see Paul Carden's side climb into the play-offs.
Boro are boosted with the double-signing news of Josh Barrett and Dominic Roma, whilst manager John Deacey insists he is 'confident' he can improve the side after just one win in eight.
“I’m confident in my abilities as a manager, you have to be and I believe we can kick on and achieve something with Scarborough," Deacey told The Scarborough News.
“I don’t do this for the money and I think the fans know that - I do it because I love the game.
Meanwhile Buxton host South Shields, who have only dropped five points this season with one loss and one draw.
Atherton Collieries face third-placed Basford United, who have won two of their last three league fixtures, and FC United of Manchester will take on Bamber Bridge.
Gainsborough Trinity, who are looking to jump out of the relegation zone, play seventh-placed Mickleover Sports at The Northolme.
Grantham Town host Radcliffe, boosted by the extended loan of Tyrese Sinclair until the 1st January.
The last four games include Hyde United vs Ashton United, Witton Albion vs Stalybridge Celtic, Nantwich Town vs Lancaster City, whilst Stafford Rangers search for their first win of the season as they travel to Morpeth Town.
To view all the weekend's games, visit the BetVictor Northern Premier fixtures page.
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