Danns will be assisted by Mark Duffy while the Silkmen search for a long-term successor to outgoing boss Dave McNabb.
McNabb departed the club in the wake of their 4-0 victory over Ramsbottom United, less than two months after succeeding former incumbent Danny Whitaker.
Last weekend’s victory saw them move six points clear at the top of the Pitching In NPL West Division.
Danns had previously joined Macclesfield on a non-contract basis in September 2021.
He boasts a wealth of Football League experience and has also represented Guyana at international level.
Completing the interim coaching team will be existing first team mentor Sammy McIlroy and Peter Band.
Danns is set to take charge for the first time on Saturday as the Silkmen visit Clitheroe, who currently sit in the play-off places.
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