Radcliffe are currently six points clear at the division's summit but could see that gap closed to three, should the Blues extend their recent run of form.
Michael Clegg's side will arrive at the Neuven Stadium full of confidence, having ran out 7-2 winners at home to Stafford Rangers a week ago.
Below them, Ashton United will hope to capitalise on a Rylands slip-up and climb to second. That can only happen if league leaders Radcliffe win and the Robins pick up maximum points at home to Workington.
Elsewhere, Worksop Town host FC United of Manchester as they look to end their four-game winless run in the league.
The Tigers led 3-1 at Workington in midweek but ended up settling for a point after conceding two late goals.
Macclesfield, who occupy the final play-off spot, will hope to maintain their position in the top five when they host a Bradford Park Avenue outfit struggling at the wrong end of the table.
Of the day's other games, notable match-ups include a hotly-contested battle between play-off hopefuls Guiseley and Hyde United at Nethermoor, and a Marine home game against last season's beaten play-off semi-finalists Gainsborough Trinity.
All fixtures will take place on Saturday 16 December at 3pm, unless stated otherwise.
Fixtures - Saturday 16 December
Ashton United v Workington
Atherton Collieries v Whitby Town
Bamber Bridge v Matlock Town
Guiseley v Hyde United
Ilkeston Town v Marske United
Macclesfield v Bradford Park Avenue
Marine v Gainsborough Trinity
Morpeth Town v Basford United
Radcliffe v Warrington Rylands
Stafford Rangers v Lancaster City
Worksop Town v FC United of Manchester
Click here for the latest fixtures from the NPL East Division, NPL Midlands Division and NPL West Division.
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